Research Progress in Hypoxia Tumor Microenvironment with Spleen Deficiency, Blood Stasis and Phlegm Retention
10.3969/j.issn.1005-5304.2018.07.033
- VernacularTitle:脾虚、血瘀及痰饮与乏氧肿瘤微环境研究进展
- Author:
Si-Qi ZHANG
1
;
Kai-Wen HU
;
Tian ZHOU
Author Information
1. 北京中医药大学东方医院
- Keywords:
tumor;
hypoxia microenvironment;
etiology and pathogenesis;
TCM;
research and development of new drugs;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(7):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia is one of the most important characteristics of malignant tumor microenvironment, and its degree is closely related to the development and prognosis of the tumor. Hypoxia promotes neovascularization in tumor microenvironment, which leads to changes of energy metabolism and the formation of drug tolerance in tumor. Studies in recent years have shown that TCM can interfere with the occurrence and development of hypoxia tumor microenvironment in certain aspects, thus inhibiting tumor growth. This article summarized recent studies on the etiology, pathogenesis, and TCM intervention for the occurrence and development of hypoxia tumor microenvironment in terms of spleen deficiency, blood stasis, and phlegm retention, and provided a reference for clinical intervention of tumors and research and development of new drugs.
