Systematic Review of Jinkui Shenqi Pills on Hypertension
10.3969/j.issn.1005-5304.2018.07.021
- VernacularTitle:金匮肾气丸加减干预高血压病系统评价
- Author:
Xiao-Rong CUI
1
;
Xue-Zhu MA
;
Qiu-Yan LI
Author Information
1. 北京市密云区医院
- Keywords:
Jinkui Shenqi Pills;
hypertension;
randomized controlled trials;
systematic review;
Meta-analysis
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(7):87-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of Jinkui Shenqi Pills on hypertension through Meta-analysis and systematic review. Methods Articles about intervention of modified Jinkui Shenqi Pills in hypertensive clinical randomized controlled trials were retrieved from CNKI, Wanfang database, VIP, Cochrane Library, PubMed, and Embase. They were all searched from inception to June 2016. Cochrane system evaluation manual bias risk assessment method was used to evaluate the quality of the articles, and RevMan5.3 software was used for Meta-analysis. Results Nine articles involving 776 cases were included in the study. Meta-analysis showed that the total effective rate of modified Jinkui Shenqi Pills was better than that of conventional Western medicine treatment [OR=2.67, 95%CI (1.73, 4.11), P＜0.000 01], and combination therapy was superior to conventional Western medicine alone [OR=3.27, 95%CI (1.99, 5.39), P＜0.000 01]. However, the efficacy of modified Jinkui Shenqi Pills alone was equivalent to the conventional Western medicine alone [OR=1.16, 95%CI (0.43, 3.09), P=0.77). Conclusion Modified Jinkui Shenqi Pills can improve the clinical symptoms of the patients with hypertension, and combination treatment can improve the antihypertensive effect. However, the quality of the included research literature is too low, yet more large-scale, multi-center, high-quality clinical randomized controlled trials are needed to further verify.
