Prescription Optimization and Evaluation of Quality of Gentiopicroside Nanoemulsion
10.3969/j.issn.1005-5304.2018.07.015
- VernacularTitle:龙胆苦苷纳米乳处方优化及其质量评价
- Author:
Peng-Fei XIA
1
;
Xiao MA
;
Guo-Tai WU
;
Yang LI
;
Qin FAN
;
Lei ZHAO
Author Information
1. 甘肃中医药大学
- Keywords:
gentiopicroside;
nanoemulsion;
preparation technology;
quality evaluation
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(7):62-66
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize prescription of gentiopicroside nanoemulsion; To evaluate its quality and security. Methods According to the basic properties of gentiopicroside, single-factor test and pseudo-ternary phase diagram were adopted to optimize prescription of gentiopicroside nanoemulsion. The physicochemical property was investigated, and the content was evaluated by HPLC. Results Optimal prescription was obtained as gentiopicroside/ethyl acetate/ EL-35/ absolute ethyl alcohol/ ultrapure water (1.77:7.66:5.94:11.91:72.71); the particle size of nanoemulsion was 23.08 nm; the content of gentiopicroside was determined by HPLC; the specificity of the method was good with a linear range of 0.004 28–0.214 mg/mL; stability of prepared gentiopicroside nanoemulsion was good in the state of different temperatures, illumination intensity and humidity conditions, without significant changes. Conclusion The optimized preparation technology of gentiopicroside nanoemulsion is simple, repeatable and stable, which can provide references for improving the bioavailability of gentiopicroside.
