Clinical Observation of Xiaotan Tongluo Gel Combined with Mecobalamin Tablets in Ttreating Peripheral Neurotoxicity Induced by Chemotherapy
10.3969/j.issn.1005-5304.2018.07.004
- VernacularTitle:消痰通络凝胶联合甲钴胺片治疗化疗诱导性周围神经病变临床研究
- Author:
Jing-Yu XU
1
;
Xuan ZHANG
;
Xiao-Wei WANG
;
Zhi-Feng QIN
;
Ji-Gui TANG
;
Ye LU
;
Pin-Kang WEI
Author Information
1. 第二军医大学长征医院中医科
- Keywords:
Xiaotan Tongluo Gel;
peripheral neurotoxicity induced by chemotherapy;
peripheral neurotoxicity
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(7):11-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical efficacy of Xiaotan Tongluo Gel combined with mecobalamin tablets in treating chemotherapy-induced peripheral neuropathy (CIPN). Methods Totally 67 cases of CIPN were divided into the treatment group (36 cases) and the control group (31 cases). Both groups were given mecobalamin tablets, 0.5 mg each time, three times a day, orally. Patients in the treatment group were treated with Xiaotan Tongluo Gel for external use at the same time. The patients in control group were treated with placebo gel for external use, 1 mL/cm2, rubbed on the skin 1 cm more than sensory obstruction in diameter. The treatment for both groups lasted for 14 d as a treatment course, and the treatment lasted for 2 courses. The changes of peripheral nerve toxicity, TCM syndrome scores and the nerve conduction velocity were observed in the two groups. Results On the 14th and 28th days of treatment, the total effective rates of peripheral nerve toxicity were 75.00% and 91.67% in the treatment group, and 38.71% and 67.74% in the control group, and the treatment group was significantly better than those of the control group (P=0.002, P=0.005); On the 14th and 28th days of treatment, the total effective rate of TCM efficacy in the treatment group was 75.00% and 94.44% respectively, and that in the control group was 45.16% and 64.52% respectively, and the treatment group was significantly better than the control group (P=0.018, P=0.005). Compared with before treatment, the TCM syndrome scores in both groups were significantly reduced on the 14th and 28th days (P＜0.01); The TCM syndrome scores in the treatment group were significantly lower than those in the control group at the same time points after treatment (P＜0.01). Compared with before treatment, the sensory and motor nerve conduction speeds of the peroneal and median nerves in the two groups at 14th and 28th days were significantly increased (P＜0.01); Comparing the two groups at the same time point after treatment, the sensory and motor nerve conduction velocity of the peroneal and median nerves in the treatment group was significantly better than that in the control group (P＜0.05, P＜0.01). Conclusion Xiaotan Tongluo Gel combined with mecobalamin tablets can effectively improve the peripheral neurotoxicity induced by chemotherapy, TCM syndrome scores, and the nerve conduction velocity.
