Study on in Vitro Release of Salvianolic Acid Bioadhesive Floating Pellets and Pharmacokinetics in Rats
10.3969/j.issn.1005-5304.2018.06.019
- VernacularTitle:丹参总酚酸生物黏附漂浮微丸体外释放和大鼠药代动力学研究
- Author:
Dan-Dan YANG
1
;
Ying LI
;
Chun-Yan ZHU
Author Information
1. 中国医学科学院北京协和医学院药用植物研究所
- Keywords:
salvianolic acid;
bioadhesive floating;
pellets;
release in vitro;
pharmacokinetics
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(6):77-81
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare salvianolic acid bioadhesive floating pellets; To prolong its residence time in vivo; To improve the oral bioavailability. Methods Salviae miltiorrhizae total phenolic acid adhering floating pellets were prepared by extrusion-spheronization. Chitosan, HPMC and carbomer were used as adherent material, stearyl alcohol was used as floating material and MCC as forming agent. The in vitro release of two adherent floating pellets were prepared and their bioavailability in rats were investigated. Results The results of in vitro release test showed that the salvianolic acid B in the blank pellets was completely released at 4 h, and the two adherent floating pellets prepared in vitro were released for 12 h. The results of pharmacokinetic studies in rats showed that after intragastric administration of salvianolic acid, salvianolic acid chitosan pellets and salvianolic acid HPMC pellets, Tmaxwere (12.00±2.74)min, (17.00±7.58)min and (27.00±12.55)min, respectively. The relative bioavailability of salvianolic acid chitosan pellets and salvianolic acid HPMC pellets were 177.08% and 172.03%, respectively. Conclusion Salvia total phenolic acid adherent floating pellets release slowly in vitro, and floating pellets can prolong the retention time in vivo and increase the oral bioavailability of salvianolic acid in rats.
