Effects of Cornel Iridoid Glycoside on Learning-memory Ability and Brain Pathological Changes in Vascular Dementia Rats
10.3969/j.issn.1005-5304.2018.06.014
- VernacularTitle:山茱萸环烯醚萜苷对血管性痴呆大鼠学习记忆能力及脑组织病理变化的影响
- Author:
Min MENG
1
;
Cui-Cui YANG
;
Li ZHANG
;
Ya-Li LI
;
Lan ZHANG
;
Lin LI
Author Information
1. 首都医科大学宣武医院药学部
- Keywords:
corneliridoid glycoside;
bilateral common carotid artery ligation;
vascular dementia;
cognitive impairment;
neuronal survival;
choline acetyltransferase;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(6):56-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of cornel iridoid glycoside (CIG) on the learning-memory ability and pathological changes in the brain of vascular dementia (VD) rats; To discuss relevant mechanism of action. Methods SD rats were randomly divided into sham-operation group, model group, positive medicine group, CIG groups low-, medium- and high-dose groups. The animal model of VD was replicated by permanent bilateral common carotid artery occlusion (2VO) in rats. Drugs were intragastrically administered 6 h after surgery and then once a day for 3 months. Morris water maze test was used to detect spatial learning-memory ability, and recognition memory was measured by the object recognition test. Immunohistochemical staining was used to detect the neuronal survival and the expression of choline acetyltransferase (ChAT) in the brain. Results Three months after permanent 2VO operation, the model rats showed a longer escape latency in Morris water maze, a lower discrimination index in the object recognition test, and a decrease in NeuN positive neuronal survival and ChAT expression in the hippocampus and cerebral cortex. Compared with the model group, intragastric administration of CIG for 3 months shortened the escape latency in Morris water maze, elevated the discrimination index in the object recognition test, and increased the NeuN positive neuronal survival in the hippocampus and cerebral cortex and ChAT expression of 2VO rats. Conclusion CIG can improve the cognitive impairment of VD model rats through protecting neurons and promoting ChAT expression.
