Effects of Electroacupuncture on Learning and Memory Ability and Brain Inflammatory Factor in Rats with Vascular Cognitive Impairment
10.3969/j.issn.1005-5304.2018.06.010
- VernacularTitle:电针对血管性认知障碍大鼠学习记忆能力及脑组织炎症因子的影响
- Author:
Qi FENG
1
;
Hua-Jie SHANG
;
Mei-Qi LIU
;
Zhao-Yan LIN
;
Ling-Hui QIU
;
Ying-Ying ZANG
;
Xin-Li CHEN
;
Yue-Ting LIU
;
Hui-Yun CHEN
;
Zhao-Yang WANG
Author Information
1. 北京中医药大学针灸推拿学院
- Keywords:
vascular cognitive impairment;
electroacupuncture;
Baihui;
Zusanli;
inflammatory factor;
learning and memory ability;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(6):39-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of electroacupuncture on the learning and memory ability and cerebral cortex inflammatory factor of rats with vascular cognitive impairment (VCI); To discuss the mechanism of electroacupuncture for preventing and treating VCI. Methods VCI rat models were made in microemboli injection through internal carotid artery method. The successful modeled rats were randomly divided into model group, positive medicine group and electroacupuncture group, and normal rats were taken as control group. Three days after rat models were established, the positive medicine group was given donepezil hydrochlorideby gavage, and electroacupuncture group was given electroacupuncture at "Baihui" and "Zusanli" acupoints. After treatment, the learning and memory ability was detected by Morris water maze test. The contents of TNF-α, IL-6 and IL-1β in rat brain tissue were detected by ELISA. Results The water maze results showed that with the increase of the number of training, the average escape latency of rats to find platform in positive medicine group and electroacupuncture group all had different degrees of shortening in positioning cruise experiment; in space exploration experiment, positive medicine group and electroacupuncture group to cross the platform area for the first time were significantly reduced compared with the model group; compared with the control group, the contents of TNF-α, IL-6 and IL-1β in the model group were increased significantly; compared with the model group, the contents of TNF-α, IL-6 and IL-β in postive medicine group and electroacupuncture group were decreased. Conclusion Electroacupuncture at "Baihui"and "Zusanli" acupoints can decrease the contents of TNF-α, IL-1 and IL-6 in the cortex of VCI rats, and improve the learning and memory ability of rats.
