Optimization of Extraction Technology for Qinhao Nasal Drops by Multi-index Comprehensive Evaluation Method
10.3969/j.issn.1005-5304.2018.04.017
- VernacularTitle:多指标综合评分法优选芩蒿滴鼻剂提取工艺
- Author:
Yan MAO
1
;
Zhen-Dong CHEN
;
Zheng-Yi GU
;
Jin-Hua HE
;
Xiao-Cui CAI
;
Yan LIU
Author Information
1. 新疆维吾尔自治区药物研究所
- Keywords:
Qinhao Nasal Drops;
extraction process;
orthogonal test;
rupestonic acid;
chlorogenic acid;
pseudoephedrine hydrochloride;
total flavonoids
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(4):82-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize extraction process of Qinhao Nasal Drops by multi-index comprehensive evaluation Method. Methods With L9(34) orthogonal design, the content of rupestonic acid, chlorogenic acid, pseudoephedrine hydrochloride, total flavonoids and extract yield were set as indexes, and extraction technology of Qinhao Nasal Drops was optimized.Results Optimum extraction technology was:12 times amount of 60% ethanol, extracted three times. Conclusion The optimized extraction technology is simple, practical, and adapt to the production needs, which can be used as the basis for reasonable development of the preparation.
