Effects of the Effective Constituents of Min Angelicae Sinensis Radix on Hyperhomocysteinemia Induced Rabbit Atherosclerotic Lesions
10.3969/j.issn.1005-5304.2018.02.012
- VernacularTitle:岷当归有效成分对高同型半胱氨酸血症致兔动脉粥样硬化的影响
- Author:
Xiao-Ping WANG
1
;
Ming-Wang ZHOU
;
Kai-Biao KANG
;
Chun-Lu YAN
;
Yan-Yi LI
Author Information
1. 甘肃省中医院
- Keywords:
hyperhomocysteinemia;
atherosclerosis;
Angelicae Sinensis Radix volatile oil;
Angelicae Sinensis Radix polysaccharide;
ferulic acid;
rabbits
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(2):51-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of three effective constituents of Min Angelicae Sinensis Radix on hyperhomocysteinemia (HHcy) induced rabbit atherosclerotic lesions (AS).Methods Forty eight Japanese big ear rabbits were randomly divided into normal group, model group, Angelicae Sinensis Radix volatile oil group, Angelicae Sinensis Radix polysaccharide group, ferulic acid group and folic acid group, with 8 rabbits in each group. The HHcy rabbit model induced AS was duplicated by injected DL-methionine. After 8 weeks, each medication group was given relevant medicine for gavage. After 12 weeks, Hcy, TC, TG, HDL-C and LDL-C level in serum were detected, and abdominal aorta vascular ultrasound were observed.Results The model group was higher than the normal group in the level of Hcy (P<0.05). Compared with the model group, the levels of Hcy in Angelicae Sinensis Radix volatileoil group, the ferulic acid group and the folic acid group decreased (P<0.05). Compared with the model group, the levels of TC, TG and LDL-C in AngelicaeSinensis Radix volatile oil group, ferulic acid group and folic acid group decreased (P<0.05). Abdominal aorta ultrasonography showed that the degree of AS was significantly attenuated in folic acid group, Angelicae Sinensis Radix volatile oil group and ferulic acid group.Conclusion Angelicae Sinensis Radix volatile oil and ferulic acid in Min Angelicae Sinensis Radix can reduce the harm to endothelium and can prevent and treat HHcy caused by rabbit AS.
