Effects of Xingbi Wenmin Gel on Serum Levels of IL-4, TGF-β1 and Nasal Mucosa Eosinophils in Allergic Rhinitis Rats
10.3969/j.issn.1005-5304.2018.02.011
- VernacularTitle:醒鼻温敏凝胶剂对变应性鼻炎大鼠血清白细胞介素-4、转化生长因子-β1和鼻黏膜嗜酸性粒细胞的影响
- Author:
Cai-Xia QIU
1
;
Jian ZHENG
;
Dong-Hong LIN
;
Si AI
;
Bo WU
;
Xiang-Li ZHUANG
;
Ke-Han WENG
;
Xu-Wei LI
Author Information
1. 福建中医药大学附属人民医院
- Keywords:
Xingbi Wenmin Gel;
IL-4;
TGF-β1;
eosinophilia counts;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(2):47-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of Xingbi Wenmin Gel on serum levels of IL-4, TGF-β1 and nasal mucosa eosinophils (EOS) in allergic rhinitis (AR) rats; To discuss its mechanism of action. Methods Intraperitoneal injection of egg albumin and aluminum hydroxide based sensitized to ovalbumin challenge 2％ local AR model was established successfully. The experimental rats were randomly divided into normal group, model group, positive control group, and Xingbi Gel low-, medium-, and high-dosage groups. Each medication group was given relevant medicine for intervention. The rat symptom scores in each group were compared, and serum IL-4, TGF-β1, and nasal mucosa EOS counts were detected. Results Compared with the normal group, the serum levels of IL-4 and TGF-β1 in model group increased significantly (P<0.01), and the nasal mucosa EOS counts increased significantly (P<0.05). Compared with model group, the serum levels of IL-4 and TGF-β1 in Xingbi Gel medium-dosage group and positive control group decreased significantly (P<0.01), and the nasal mucosa EOS counts decreased significantly (P<0.05). Conclusion Xingbi Wenmin Gel may be effective through down-regulation of IL-4, TGF-β1 levels of inflammatory factors, and reduction of EOS infiltration in nasal mucosa.
