Clinical Study on Chaishao Liujunzi Decoction Combined with Chemotherapy in Treating Advanced Pancreatic Cancer
10.3969/j.issn.1005-5304.2018.02.006
- VernacularTitle:柴芍六君子汤辅助化疗治疗肝郁脾虚型中晚期胰腺癌临床研究
- Author:
Hua LIU
1
;
Jing WU
;
Tong-Lin SUN
Author Information
1. 湖南中医药大学第一附属医院
- Keywords:
advanced pancreatic cancer;
Chaishao Liujunzi Decoction;
capecitabine
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2018;25(2):26-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and analyze the clinical efficacy of Chaishao Liujunzi Decoction combined with chemotherapy in the treatment of advanced pancreatic cancer with liver depression and spleen deficiency. Methods Totally 60 cases of advanced pancreatic cancer patients were divided into treatment group and control group according to random number table method, with 30 cases in each group. Both groups were given nutritional support, to maintain electrolyte balance, three levels of painkiller and anti-infective and other basic treatment. Patients in the treatment group were treated with capecitabine monotherapy, 1250 mg/m2 per time, twice a day, 30 min after dinner, orally, for two weeks and one week off for a chemotherapy cycle, a total of two cycles of chemotherapy. While patients in the treatment group were additionally treated with Chaishao Liujunzi Decoction, 1 dosage per day for morning and evening, for 6 weeks. Followed up for 4 weeks. Efficacy of solid tumor, TCM symptom efficacy and serum gastrointestinal cancer antigen (CA19-9) in two groups were compared; KPS scores before and after treatment were observed; chemotherapy toxicity was monitored. Results Totally 59 patients completed the observation and the control group lost 1 case. After treatment, the tumor stability rate of the control group and the treatment group were 76.7％ (23/30) and 65.5％ (19/29) respectively, without statistical significance (P>0.05). The total effective rate of symptom efficacy was 90％ (27/30) in the treatment group and 69％ (20/29) in the control group, with statistical significance (P<0.05). The efficacy of serum19-9 of the treatment group was better than the control group (P<0.05). 2 groups had varying degrees of chemotherapy toxicity (P<0.05). Conclusion Chaishao Liujunzi Decoction combined with chemotherapy in the treatment of advanced pancreatic cancer can improve the main clinical symptoms, decrease serum CA19-9, and reduce the adverse reactions caused by chemotherapy.
