Progress in identifying genetic susceptibility genes for familial breast cancer
10.3969/j.issn.1000-8179.2018.21.946
- VernacularTitle:乳腺癌家系遗传易感基因研究进展
- Author:
Hailian ZHANG
1
;
Shichao ZHANG
;
Jinpu YU
Author Information
1. 天津医科大学肿瘤医院乳腺二科
- Keywords:
familial breast cancer;
genetic susceptible genes;
gene screening technology;
treatment
- From:
Chinese Journal of Clinical Oncology
2018;45(21):1113-1116
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is the most common malignant tumor in women. With the development of cell biology and molecular bio-technology, great progress has been made in the study of the pathogenesis of breast cancer. Familial breast cancer is closely related to the mutation of susceptible genes. Selected susceptible genes of breast cancer can be grouped into three categories: high-, medium-, and low-penetrance susceptible genes. The means of identifying the high-risk sites of pathogenic mutation and genetic polymorphism is the focus of research on the genetic predisposition of breast cancer.
