Endoreplication and its role in tumor development and progression
10.3969/j.issn.1000-8179.2018.20.885
- VernacularTitle:内复制及其在肿瘤发生发展中的作用
- Author:
Lisha QI
1
;
Jingyi WANG
;
Yalei WANG
;
Zhiyong LIU
;
Wenfeng CAO
Author Information
1. 天津医科大学肿瘤医院病理科
- Keywords:
endoreplication;
cell cycle;
polyploid giant cancer cells;
tumor
- From:
Chinese Journal of Clinical Oncology
2018;45(20):1071-1074
- CountryChina
- Language:Chinese
-
Abstract:
Most diploid cells proliferate by proceeding through the canonical G1 (DNA pre-synthesis), S (DNA synthesis), G2 (DNA post-synthesis), and M(mitosis) phases of the cell cycle. However, there is another type of cell cycle that occurs frequently in both plants and animals, known as endoreplication. Endoreplication consists of alternating periods of G and S phases without cytokinesis, which results in polyploidy. It is indispensable for normal development, organ formation, and wound healing in humans. In recent years, con-siderable attention has been paid to delineating the connections of endoreplication with tumorigenesis and tumor progression. Here, we review the role of endoreplication in normal human development and discuss its possible role in tumor development and the un-derlying molecular mechanisms.
