Relationship between mammographic features and molecular subtypes in invasive breast cancer patients
10.3969/j.issn.1000-8179.2018.20.902
- VernacularTitle:浸润性乳腺癌X线影像学表现与其分子分型的相关性研究
- Author:
Jing LIU
1
;
Yu JI
;
Fangfang LI
;
Yang CAO
;
Peifang LIU
Author Information
1. 天津医科大学总医院医学影像科 天津市300052
- Keywords:
mammography;
breast cancer;
molecular subtypes
- From:
Chinese Journal of Clinical Oncology
2018;45(20):1049-1052
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the relationship between mammographic features and molecular subtypes in invasive breast cancer pa-tients. Methods: We performed a retrospective review of mammographic images from a total of 182 histopathologically diagnosed-breast cancer patients treated in Tianjin Medical University General Hospital and Tianjin Medical University Cancer Institute and Hospi-tal between January 2016 and March 2016. Mammographic features were assessed according to the Breast Imaging Reporting and Da-ta System(BI-RADS). Molecular subtypes were classified according to the St Gallen International Expert Consensus. Statistical analysis was performed to assess the correlation between mammographic features and molecular subtypes of breast cancer. Results: There was a relationship between mammographic calcifications and molecular subtypes of invasive breast cancer (V=0.221, P<0.05). In com-parison with Luminal A (12/20), Luminal B (80/132), and HER-2 enriched (4/10) breast cancers, most triple-negative breast cancers (18/20) were non-calcified lesions (P<0.05). The proportion of spiculated masses was higher in Luminal breast cancer (30/85) than in non-Luminal breast cancer (1/16) (P<0.05). Conclusions: There is a relationship between mammographic features and molecular subtypes of invasive breast cancer.
