Expression and significance of NAD (P) H: quinone oxidoreductase 1 and heme oxygen-ase-1 proteins in T-cell lymphoma
10.3969/j.issn.1000-8179.2018.20.920
- VernacularTitle:NQO1和HO-1在T细胞淋巴瘤中的表达及意义
- Author:
Jing ZHANG
1
;
Li XUE
;
Yamei DANG
;
Fenghui ZHAO
;
Hongling LI
Author Information
1. 甘肃省人民医院肿瘤内科 兰州市730000
- Keywords:
T cell lymphoma;
NAD (P) H:quinone oxidoreductase 1 (NQO1);
heme oxygenase-1 (HO-1);
immunohistochemistry
- From:
Chinese Journal of Clinical Oncology
2018;45(20):1033-1037
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of NAD (P) H: quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) in T-cell lymphoma (TCL), and investigate the correlation between these two indicators and other clinicopathological parameters in TCL. Methods: Clinical data of 61 patients with TCL who were initially diagnosed in Gansu Provincial Hospital were analyzed retrospectively. Immunohistochemical examination was performed to detect NQO1 and HO-1 expression levels in 61 TCL tissues (TCL group) and 20 lymph node reactive hyperplasia tissues (control group). Results: Positive expression rates of NQO1 and HO-1 were significantly higher in TCL tissues than in lymph node reactive hyperplasia tissues (P<0.05). NQO1 expression was closely related with Ann-Arbor clinical stage and B symptoms (P<0.05); HO-1 expression was correlated with clinical stage, bone marrow invasion, and B symptoms (P<0.05). NQO1 and HO-1 expression levels were not related to age, sex, lactate dehydrogenase level, and pathological type (P>0.05); there was a correlation between NQO1 and HO-1 expression (r=0.264; P=0.040). Conclusions: NQO1 and HO-1 are highly expressed in TCL and may interact and contribute to the occurrence and development of TCL.
