The effect of drug transporter gene polymorphisms on susceptibility to imatinib in chronic myelogenous leukemia
10.3969/j.issn.1000-8179.2018.12.245
- VernacularTitle:药物蛋白核苷酸多态性对靶向药物伊马替尼敏感性的影响
- Author:
Wenjuan OUYANG
1
;
Qin XIAO
;
Yalan ZHANG
Author Information
1. 中南大学湘雅医院国家药物临床试验中心 长沙市410008
- Keywords:
drug transporter;
gene polymorphisms;
imatinib;
chronic myelogenous leukemia (CML)
- From:
Chinese Journal of Clinical Oncology
2018;45(12):638-642
- CountryChina
- Language:Chinese
-
Abstract:
As a first generation tyrosine kinase inhibitor, imatinib is the gold standard drug for the clinical treatment of chronic myelog-enous leukemia. However, interindividual differences in resistance and response to imatinib have been widely observed. In vivo and in vitro studies have confirmed that ATP-binding cassette transporters, organic cation transporters, and organic anion transporting poly-peptides have a large effect on imatinib pharmacokinetics and pharmacodynamics. In addition, the gene polymorphisms of drug trans-porters can directly or indirectly influence the intracellular concentration of imatinib, resulting in differences in treatment efficacy among chronic myelogenous leukemia patients. This review profiles the effect of drug transporter gene polymorphisms on susceptibili-ty to imatinib in chronic myelogenous leukemia so as to provide reference to further clinical researches.
