Research progress on tumor immune microenvironment evaluation in efficacy predic-tion
10.3969/j.issn.1000-8179.2018.12.266
- VernacularTitle:肿瘤免疫微环境评价在疗效预测中的研究进展
- Author:
Hua ZHAO
1
;
Feng WEI
;
Xiubao REN
Author Information
1. 天津医科大学肿瘤医院生物技术研究室
- Keywords:
immunoscore;
immune landscape;
prognostic biomarker;
tumor immune microenvironment
- From:
Chinese Journal of Clinical Oncology
2018;45(12):599-603
- CountryChina
- Language:Chinese
-
Abstract:
With the clinical applications of new immunotherapies, traditional TNM staging has been unable to meet the clinical needs of curative effect predictions. It is known that the immunological features of the tumor immune microenvironment play important roles in tumor prognosis evaluations. Recently, the immunoscore system, which is based on local immune cell distribution and density, has gradually become an important indicator for prognosis evaluations and has been verified in several tumor researches. Recently, with the application of new mass flow detection and single cell sequencing technologies, the number of immune landscape studies have also been increasing, and new tumor-specific immune cell subsets have been identified. These subtypes not only provide individ-ualized immunotherapy guidelines for patients, but also provide potential new targets for the further development of new immuno-therapy strategies. This review will introduce recent research progress in this field.
