Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Chronic Obstructive Pulmonary Disease in Korean Population.
10.4046/trd.2006.60.6.638
- Author:
Joo Ock NA
1
;
Myung Ho OH
;
Jae Sung CHOI
;
Ki Hyun SEO
;
Yong Hoon KIM
Author Information
1. Department of Internal Medicine, Soonchunhyang University Collage of Medicine, Cheonan, Korea. juokna@schch.co.kr
- Publication Type:Original Article
- Keywords:
Surfactant;
SP-A;
SP-A alleles;
Genotype of SP-A;
COPD;
Genetic polymorphism
- MeSH:
Alleles;
Genotype;
Humans*;
Infant, Newborn;
Polymerase Chain Reaction;
Polymorphism, Genetic;
Polymorphism, Restriction Fragment Length;
Pulmonary Disease, Chronic Obstructive*
- From:Tuberculosis and Respiratory Diseases
2006;60(6):638-644
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUNDS: This study investigated whether or not a polymorphism in the gene encoding the surfactant protein A(SP-A) has any bearing on the individual susceptibility to the development of chronic obstructive pulmonary disease(COPD) in a genetically homogenous Korean population. METHODS: The genotypes of 19 COPD patients and 20 healthy neonates as controls were tested using a polymerase chain reaction followed by restriction fragment length polymorphism analysis for the SP-A gene. RESULTS: The specific frequencies of the 6A2 and 6A18 alleles of SP-A1 and the 1A2 allele of SP-A2 were much higher in the COPD group than control group (p<0.05). However, the frequencies of the 6A3 and 6A4 alleles of SP-A1 and the 1A0 allele of SP-A2 in the COPD group were significantly lower than the control group. In the COPD group, the frequencies of the +50 locus genotypes GG of SP-A1 and the +9 locus genotypes CC of SP-A2 were 85.0% and 60.6%, respectively, and 19.7% and 24.8% in the control group, respectively. The frequencies of the polymorphic genotypes or alleles showed a statistically significant difference between the COPD group and the control group (P<0.05). CONCLUSION: A genetic polymorphism in SP-A is associated with the development of COPD in the Korean population.
