Research progress of plasma EBV DNA detection in the diagnosis and treatment of na-sopharyngeal carcinoma
10.3969/j.issn.1000-8179.2018.10.172
- VernacularTitle:血浆EBV DNA检测在鼻咽癌诊疗中的研究新进展
- Author:
Jingao LI
1
;
Shaojun LIN
;
Xiaozhong CHEN
Author Information
1. 江西省肿瘤医院放疗科 南昌市330029
- Keywords:
nasopharyngeal carcinoma;
EBV DNA;
diagnosis;
screening
- From:
Chinese Journal of Clinical Oncology
2018;45(10):487-491
- CountryChina
- Language:Chinese
-
Abstract:
Nasopharyngeal carcinoma is one of the most common malignant tumors in the southern part of China. The main etiologi-cal factors of nasopharyngeal carcinoma include genetic susceptibility, dietary factors, and Epstein-Barr virus (EBV) infection. EBV de-oxyribonucleic acid (EBV DNA) can be persistently detected in the plasma of patients with nasopharyngeal carcinoma, and its levels correlate with the disease stage. After successful treatment, EBV DNA is rapidly cleared from the plasma of patients;however, signifi-cant increases in plasma EBV DNA levels are observed in patients with recurrent or metastatic diseases after treatment. Accumulating evidence suggests that EBV DNA detection is useful in the early diagnosis and screening, diagnosis of tumor recurrence or distant me-tastasis, prognosis, and tailored treatment of patients with nasopharyngeal carcinoma. This review summarizes the aforementioned progresses to provide a basis for future clinical and research efforts.
