Role of different phenotype tumor-associated macrophages in tumor progression

VernacularTitle:不同表型肿瘤相关巨噬细胞在肿瘤进展中的作用
Author: Haoyue GUO ¹ ; Rui MAO ; Ran WANG ; Erjia ZHU ; Donglai CHEN
Author Information

1. 同济大学医学院临床医学一系上海市200092
Keywords: tumor-associated macrophages; phenotype; neoplasms metastasis
From: Chinese Journal of Clinical Oncology 2018;45(9):482-486
CountryChina
Language:Chinese
Abstract: Innate immune cells are highly represented in the tumor microenvironment,and among the most abundant of these are macrophages.However,macrophages are broadly categorized as"classically activated"pro-inflammatory M1 macrophages and"alter-natively activated"anti-inflammatory M2 macrophages,which might be too simplified to describe the various phenotypes and func-tions of tumor-associated macrophages(TAMs).Most TAMs are now reclassified into CD68+TAM,CD163+TAM,CD204+TAM,CD169+TAM,and CCL18+TAM,among others,according to the different expression of surface proteins.These surface proteins have different types of ligands and regulate different signaling pathways and cytokines.Therefore,even if these subtypes of TAMs have similar ef-fects of promoting or inhibiting tumors,the mechanisms involved and the induced clinical manifestations are different.In this paper, the effects of various phenotypes of TAMs on tumor growth,metastasis,prognosis,and clinical relevance are reviewed.