CPEB4 expression in patients with non-small cell lung cancer and its prognostic value
10.3969/j.issn.1000-8179.2018.09.435
- VernacularTitle:CPEB4在非小细胞肺癌中表达及其对预后的预测价值
- Author:
Aiying QIN
1
;
Tiejun REN
;
Jianfeng HOU
;
Chang LIU
;
Fengxiao SHAN
;
Xiangle XIONG
;
Jing CHEN
Author Information
1. 郑州大学附属洛阳市中心医院肿瘤三科 河南省洛阳市471000
- Keywords:
CPEB4;
non-small cell lung cancer;
prognosis
- From:
Chinese Journal of Clinical Oncology
2018;45(9):453-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore CPEB4 expression in patients with NSCLC and its prognostic value.Methods:The CPEB4 mRNA expres-sion levels were detected by real-time quantitative PCR,while the expression levels of proteins were detected by Western blot.The protein expression in formalin-fixed samples were analyzed by immunohistochemistry.The prognostic significance of CPEB4 in NSCLC patients was investigated by Log-rank and Cox proportional hazard regression model.Results:The mRNA and protein expression levels of CPEB4 in NSCLC cell lines were both higher than those in normal lung cell line.The mRNA and protein expression levels of CPEB4 were significantly upregulated in NSCLC tissues compared to the adjacent non-tumor tissues.The CPEB4-positive expression ratio was 38.2% in the formalin-fixed samples.N stages were identified as the relative factors of CPEB4 expression(P<0.05).Cox multivariate analysis showed significant relationships between overall survival and T stage,and between N stage and CPEB4 expression.Conclu-sions:CPEB4 expression was elevated in NSCLC and was related with the prognosis.Hence,it may be a potential target in NSCLC treat-ment.
