Expression and clinical significance of coagulation factorⅢin non-small cell lung can-cer patients with hypercoagulability
10.3969/j.issn.1000-8179.2018.08.244
- VernacularTitle:凝血因子Ⅲ在非小细胞肺癌高凝状态患者外周血中的表达及其临床意义
- Author:
Wei DONG
1
;
Cunde WANG
;
Quan GONG
;
Xueqin LI
;
Lijuan ZHANG
;
Chunyan ZHOU
Author Information
1. 昆明医科大学第三附属医院
- Keywords:
coagulation factorⅢ;
hypercoagulable state;
clinical pathology;
survival period
- From:
Chinese Journal of Clinical Oncology
2018;45(8):385-389
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of coagulation factorⅢin patients with non-small cell lung cancer(NSCLC)with hyperco-agulability and its clinical significance,and to explore the relationship between its expression level and the clinicopathological features and the survival period.Methods:There were 74 patients with NSCLC with hypercoagulability and 42 without hypercoagulability,con-firmed using pathological and biochemical tests in Yunnan Cancer Hospital from January 2013 to October 2014.The enzyme-linked im-munosorbent assay(ELISA)was performed to detect the expression of serum coagulation factorⅢand its relationship with clinico-pathological features and prognosis was analyzed.Results:Serum coagulation factorⅢlevel in patients with hypercoagulable NSCLC before chemotherapy was 560.32-200.34 ng/L,which was significantly higher than that in patients without hypercoagulability(463.29-159.22 ng/L)(P=0.008),and significantly higher than that in patients after chemotherapy(471.39±160.31 ng/L)(P=0.000).Serum coag-ulation factorⅢlevel in patients with hypercoagulable state of NSCLC was related to lymph node metastasis(P=0.026),distant metas-tasis(P=0.025),and tumor-node-metastasis staging(P=0.007).They were negatively correlated with prothrombin time(r=?0.638,P=0.032)and activated partial thromboplastin time(r=?0.702,P=0.028),and positively correlated with fibrinogen(r=0.715,P=0.008)and platelets (r=0.597,P=0.007).The 1-to 3-year overall survival of patients with NSCLC with high coagulation factorⅢexpression was significantly lower than that of patients with low coagulation factorⅢexpression.Conclusions: The expression level of serum coagu-lation factorⅢin patients with high coagulation state of NSCLC is related to lymph node metastasis and TNM staging,which has cer-tain guiding significance for predicting the survival of patients.
