Progress in research on prognosis-related gene mutations in diffuse large B-cell lym-phoma through next generation sequencing

VernacularTitle:基于NGS的弥漫大B细胞淋巴瘤预后相关基因突变研究进展
Author: Shu CHEN ¹ ; Pu HUANG ; Xiaoying XU
Author Information

1. 天津医科大学肿瘤医院病理科
Keywords: diffuse large B-cell lymphoma(DLBCL); gene mutation; NGS
From: Chinese Journal of Clinical Oncology 2018;45(7):371-374
CountryChina
Language:Chinese
Abstract: Diffuse large B-cell lymphoma(DLBCL)is a highly invasive malignant lymphoma,and the molecular mechanism of its patho-genesis is not fully understood.Next generation sequencing(NGS)is an increasingly mature gene assay technology,which has been widely applied in recent years to study the genetics of DLBCL.Targeted therapy development has progressed significantly on the basis of these studies,which has made genetic mutations in DLBCL become the new research hotspot.This review summarizes the progress in research on progress-related gene mutations in DLBCL.