The clinical value of predicting the invasiveness of pulmonary mixed ground-glass nodules by CT quantitative parameters
10.3969/j.issn.1000-8179.2018.06.099
- VernacularTitle:CT定量参数预测评估肺混合磨玻璃结节侵袭性的临床价值
- Author:
Lizhu HAN
1
;
Zhaoxiang YE
;
Xubin LI
;
Peng ZHANG
;
Yidi WANG
Author Information
1. 天津医科大学肿瘤医院放射治疗科
- Keywords:
lung adenocarcinoma;
mixed ground-glass nodules;
invasiveness;
CT;
quantitative parameters
- From:
Chinese Journal of Clinical Oncology
2018;45(6):286-290
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the value of CT quantitative parameters in prediction of the invasiveness of pulmonary mixed ground glass nodules(mGGNs).Methods:CT images of 164 patients with pulmonary ground-glass nodules(mGGNs),enrolled in Tianjin Medi-cal University Cancer Institute and Hospital from January 2013 to September 2016,confirmed by surgical pathology were analyzed ret-rospectively.CT quantitative parameters including maximum diameter,largest diameter perpendicular to the maximum diameter,vol-ume on both pulmonary window and mediastinal window,mean CT value and TDR(tumor shadow disappear rate)were evaluated be-tween minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC) with ROC and Logistic regression analysis. Re-sults:Logistic regression analysis showed that the maximum diameter of the pulmonary window(OR=3.080,95% CI:1.135-8.355,P=0.027)and the maximum diameter of the mediastinal window(OR=5.881,95%CI:1.634-21.166,P=0.007)independently predicted the invasiveness of mGGNs;the corresponding values of area under the curve of the combination of two parameters were 0.855,with sen-sitivity of 77.61% and specificity of 86.67 %.The cut-off point to the corresponding value of the maximum diameter on pulmonary win-dow and mediastinal window was 1.902cm and 1.273cm,respectively.Conclusions:CT quantitative parameters are helpful in predict-ing the invasiveness of mGGNs.The maximum diameters on both pulmonary window and mediastinal window are independent predic-tors.
