A retrospective study of the effect of postoperative adjuvant therapy on patients with locally advanced pT3N0M0 esophageal squamous cell carcinoma
10.3969/j.issn.1000-8179.2018.05.050
- VernacularTitle:术后辅助治疗对局部进展期(pT3N0M0)食管鳞癌远期生存影响的回顾性分析
- Author:
Duojie ZHU
1
;
Bin LI
;
Cheng WANG
;
Peng JIANG
;
Jianbao YANG
;
Tieniu SONG
;
Xiaoping WEI
;
Yuqi MENG
Author Information
1. 兰州大学第二医院胸外科
- Keywords:
esophageal cancer;
squamous cell carcinoma;
postoperative adjuvant therapy;
overall survival;
disease free survival
- From:
Chinese Journal of Clinical Oncology
2018;45(5):228-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of postoperative adjuvant therapy on patients with locally advanced pathologic T3N0M0 (pT3N0M0)esophageal squamous cell carcinoma(ESCC).Methods:In this retrospective study,we evaluated patients who underwent esophagectomy at Lanzhou University Second Hospital.Patients were divided into 4 groups:surgery-alone(S),surgery+radiotherapy group(S+RT),surgery+chemotherapy(S+CT),and surgery+chemoradiotherapy(S+CRT)groups.Both the clinicopathologic informa-tion and the long-term follow-up results were analyzed.Results:From January 2010 to April 2014,a total of 177 patients with a medi-an age of 61 years(range 43-78),were enrolled into the study.Among them,79 received surgery alone;the remaining 98 patients re-ceived adjuvant therapy,of whom 28 patients received adjuvant radiotherapy,38 received adjuvant chemotherapy,and 32 received ad-juvant chemoradiotherapy.Overall survival and disease-free survival were better in Group S+Adjuvant than in Group S(P=0.012,P=0.007,respectively).Comparisons among the four groups showed that the overall survival was higher in Group S+CRT than in Group S (P=0.031).Group S+RT was associated with better overall survival and disease-free survival than Group S(P=0.038,P=0.011,respec-tively).Conclusions:Patients with pT3N0M0 ESCC could benefit from adjuvant radiotherapy and chemoradiotherapy,as radiotherapy could help achieve better locoregional control.
