Treatment outcomes of different induction chemotherapy regimens combined with in-tensity-modulated radiotherapy in nasopharyngeal carcinoma
10.3969/j.issn.1000-8179.2018.04.235
- VernacularTitle:不同诱导化疗方案联合放疗治疗鼻咽癌疗效分析
- Author:
Zhenzhen YIN
1
;
Youyou WANG
;
Ximei ZHANG
;
Fengming WANG
;
Lujun ZHAO
;
Ping WANG
;
Peiguo WANG
;
Zhiyong YUAN
Author Information
1. 天津医科大学肿瘤医院放射治疗科
- Keywords:
Keyword:nasopharyngeal carcinoma;
induction chemotherapy;
intensity-modulated radiotherapy;
treatment outcome
- From:
Chinese Journal of Clinical Oncology
2018;45(4):179-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The role of induction chemotherapy(IC)and preferred regimens is not very clear in non-endemic nasopharyn-geal carcinoma(NPC)in northern China.Methods:A total of 170 pathologically proven locoregional advanced NPCs between January 2012 and December 2014 were included in this analysis.One hundred and twenty-six were men and 44 patients were women.Accord-ing to the American Joint Committee on Cancer(AJCC)7th stage system,48 patients were T1-2 and 77 patients were T3-4;48 patients were N0-1 and 122 patients were N2-3;27 patients were stageⅡ,105 patients were stageⅢ,and 38 patients were stage IVa-b.Re-sults:The median follow-up time was 34 months.The 3-year overall survival(OS),locoregional failure-free survival(LRFS),distant me-tastasis-free survival(DMFS),and disease-free survival(DFS)were 82.8%,91.5%,76.7%,and 69.1%,respectively.Multivariate analyses showed that IC with TPF(docetaxel,carboplatin,and fluorouracil)or TP(docetaxel and cisplatin)presented superior DFS and DMFS compared with PF(cisplatin+5-FU)[DFS-hazard ratio(HR):1.820,95% confidence interval(CI):1.013-3.271,P=0.045;DMFS-HR:2.240, 95% CI:1.017-4.090,P=0.045].Conclusions:The IC regimens appeared to affect patients' outcomes,and TP-containing IC regimens conferred better DFS and DMFS than PF regimens.
