TP and FAC effect on patients with primary tumor molecular typing luminal A, axillary lymph node metastasis three negative breast cancer
10.3760/cma.j.issn.1008-6315.2018.06.010
- VernacularTitle:TP与FAC辅助化疗对原发灶分子分型Luminal A伴有腋淋巴结转移灶三阴性乳腺癌患者的效果影响
- Author:
Xiangxin ZHENG
1
;
Ji WU
;
Shucheng GU
;
Xiaoling JIANG
;
Xiaohong SHI
;
Mu YUAN
;
Bolin LU
;
Xing QIU
;
Xuxu ZHANG
;
Jianyin BAI
;
Xiaoqing GUAN
Author Information
1. 223800,南京鼓楼医院集团宿迁市人民医院 徐州医科大学附属宿迁医院 乳腺外科
- Keywords:
Breast cancer;
Lymph node metastasis
- From:
Clinical Medicine of China
2018;34(6):524-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application of paclitaxel or docetaxel combined with cisplatin (TP) with cyclophosphamide,pirirubicin and fluorouracil (FAC) in the primary tumor molecular typing Luminal A,axillary lymph node metastasis three negative breast cancer. Methods From January 2012 to January 2014, the clinical data of forty-nine patients with were selected. All patients were divided into two groups by balance randomization method, TP group and FAC group. Twenty-five patients were treated with TP regimen and 24 patients were treated with FAC regimen. The clinical efficacy was evaluated after six cycles of chemotherapy. Chemotherapy effects,adverse reactions and survival rates of two groups were compared. Results All patients were given intravenous chemotherapy according to the plan and were evaluated for clinical efficacy. The response rate (RR) was 64. 0％ in TP group,including 4 cases of complete remission (CR),12 cases of partial remission (PR),7 cases of stable disease(SD) and 2 cases of progressive disease(PD). The adverse reactions were gastrointestinal reactions and granulocytopenia. The median progression-free survival ( PFS) and overall survival ( OS) were respectively 12. 4 months and 34. 1 months. In FAC group,the response rate ( RR) was 33. 3％,including 2 cases of CR,6 cases of PR,11 cases of SD and 5 cases of PD. The adverse reactions were gastrointestinal reactions,granulocytopenia and premature atrial contraction. The median PFS and OS were 7. 2 months and 20. 7 months respectively. The effective rate of TP group was higher than that of FAC group (χ2=4. 608,P=0. 032),and the progression-free survival time and total survival time were longer than those of FAC group (χ2 =8. 317, 8. 563, P=0. 004, 0. 003 ) . Conclusion Compared to FAC regimen, TP regimen could improve the survival rate of patients better with breast cancer of Primary tumor Luminal A and Axillary Lymph Node Metastasis Triple negative type, and adverse reactions were tolerated, it may be an optimized chemotherapy.
