The effect of chronic kidney disease on heart failure with preserved ejection fraction and its prognosis
10.3760/cma.j.issn.1008-6315.2018.05.021
- VernacularTitle:慢性肾脏病对射血分数保留心力衰竭的影响及其预后
- Author:
Pan ZHANG
1
;
Jiani HENG
;
Yongming LIU
Author Information
1. 730000,兰州大学第一临床医学院
- Keywords:
Heart failure;
left ventricular ejection fraction;
chronic kidney disease;
calcium phosphorus metabolism
- From:Clinical Medicine of China
2018;34(5):474-477
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure (HF) is the end stage of a variety of heart diseases,with poor clinical outcome, high mortality, and an increasing incidence year by year. It is one of the most important cardiovascular diseases. Almost half of patients with heart failure have normal ejection fraction (EF),which we call heart failure with preserved ejection fraction ( HFpEF) . The incidence of HFpEF in developed countries continues to rise, which is considered to be a common danger factor,including the elder,female,and patients with hypertension, metabolic syndrome,renal dysfunction and obesity. A large number of clinical studies from home and abroad show that chronic kidney disease (CKD) will aggravate or promote the occurrence and development of HFpEF through the reaction of microvascular and vascular inflammation,nerve system activity,cardiac structure change,calcium and phosphorus metabolism disorder and so on,and the glomerular filtration rate ( eGFR) and proteinuria are closely related to the prognosis of HFpEF in CKD. To clarify the influence of CKD on HFpEF and its related mechanisms,it is of certain value to assess the condition of HFpEF and to further treat it.
