Research of the relevance between serum sLOX-1 levels and left ventricular diastolic function in patients with essential hypertension
10.3760/cma.j.issn.1008-6315.2018.04.016
- VernacularTitle:原发性高血压患者血清凝集素样氧化型低密度脂蛋白受体1水平与左心室舒张功能的相关性分析
- Author:
Jie YAN
1
;
Yanjun LIU
;
Hong ZHAO
;
Zengli DIAO
Author Information
1. 华北理工大学附属医院心内科
- Keywords:
Soluble lectin-like oxidized low density lipoprotein receptor-1;
Essential hypertension;
Left ventricular diastolic function
- From:Clinical Medicine of China
2018;34(4):362-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum lectin like oxidized low density lipoprotein receptor-1 ( sLOX-1 ) and left ventricular diastolic function in patients with essential hypertension. Methods From January 2016 to July 2017, one hundred and forty-six patients with essential hypertension were selected and divided into two groups according to the ratio of E/ A,the left ventricular diastolic function group (76 cases) and the left ventricular diastolic function group (70 cases),the sLOX-1 level of the patients was detected by ELISA method, and the left ventricular diastolic function was evaluated by echocardiography. The correlation between sLOX-1 and left ventricular diastolic function was analyzed. Results The serum sLOX-1 levels in left ventricular diastolic function group (( 208. 12 ± 13. 48 ) μg/ L ) were significantly higher than those inthe left ventricular diastolic function group ((152. 12 ± 12. 96) μg/ L) . The difference between the two groups was statistically significant (t= 6. 586,P= 0. 000). Logistic regression analysis showed that serum sLOX-1 was a influence factor of left ventricular diastolic function (OR= 2. 42,95%CI 1. 42-2. 82,P = 0. 036) . Conclusion The levels of serum sLOX-1 can be used as a indicator of left ventricular diastolic function.
