A randomized controlled study of the efficacy and safety of dexamethasone in the treatment of pain in patients with emergency trauma
10.3760/cma.j.issn.1008-6315.2018.04.012
- VernacularTitle:地塞米松治疗急诊创伤患者疼痛的有效性和安全性随机对照研究
- Author:
Rui ZHANG
1
;
Yu FENG
Author Information
1. 201112,上海交通大学医学院附属仁济医院南院骨科
- Keywords:
Dexamethasone;
Pain;
Emergency trauma
- From:Clinical Medicine of China
2018;34(4):344-347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy and safety of dexamethasone in the treatment of pain in patients with emergency trauma. Methods From December 2015 to December 2016,two hundred and sixty-four patients were enrolled in the study and randomly divided into the experimental group and the control group,each with 132 cases. In the experimental group,dexamethasone sodium phosphate injection was used as a test drug, and the control group was treated with glucose injection as a placebo. VAS score,overall evaluation,IL-6/ blood glucose and painkillers intake were recorded by physicians at the time of admission (0 h),6,12,24,48 h after injury. At the same time, wound healing, hospitalization time, fracture healing time and adverse events were recorded. Results The 24 h and 48 h VAS scores in the experimental group were (2. 31±0. 37) and (1. 21 ±0. 13) points,which were significantly lower than those in the control group ((4. 12± 0. 54) points,(3. 01 ±0. 51) points). The difference was significant ( F ( time) = 2917. 519,F( Group) = 137. 507,F ( time ?group)= 83. 927,P<0. 05). The level of IL-6 in the experimental group was (9. 51±0. 67) ng/ L,significantly lower than that in the control group (12. 43±1. 23) ng/ L. (F (time)= 3. 452×106 ,F (group) = 913. 243,F (time ?group)= 456. 891,P<0. 05). In the experimental group,one hundred and twenty-five cases were healed with the healing rate of 94. 70%,which was obviously superior to the control group (104 cases of healing and healing rate was 78. 79%) (χ2 = 14. 865,P<0. 05),and the hospitalization time of the experimental group was (15. 52±2. 51) d,which was significantly lower than that of the control group( (24. 76±3. 67) d) (t= 23. 876, P<0. 05) . The incidence of adverse reactions in the experimental group was 9. 09% ( 12/ 132),which was slightly higher than that of the control group ( 7. 58% ( 10/ 132)), but the difference was not statistically significant (t= 0. 095,P>0. 05). Conclusion The emergency use of dexamethasone can safely and effectively alleviate preoperative pain and expand the indications of dexamethasone. It is beneficial to relieve postoperative analgesia,to reduce the use of morphine and NSAID drugs,and to provide a new way for multimodal analgesia.
