Adverse Reactions Induced by Non-ionic Iodinated Contrast Agent in 20,418 Patients receiving CT Examination
10.3969/j.issn.1005-5185.2017.11.021
- VernacularTitle:20418例CT检查非离子型碘对比剂不良反应分析
- Author:
Jianxun CAO
1
;
Guoli YAO
;
Kangyan ZHANG
;
Rong WANG
;
Gang HUANG
Author Information
1. 甘肃省人民医院放射科 甘肃兰州730000
- Keywords:
Tomography,X-ray computed;
Contrast media;
Iodine;
Adverse effects;
Retrospective studies
- From:
Chinese Journal of Medical Imaging
2017;25(11):876-880
- CountryChina
- Language:Chinese
-
Abstract:
Purpose Medicine information and features of adverse reactions induced by non-ionic iodinated contrast agent injection for CT examination are analyzed and discussed,offering empirical evidence and reference for medication choice and patient information for clinical CT examination and targeted adverse reactions disposal.Materials and Methods General material,medicine type and name,adverse reactions occurrence time,symptoms and other information of the 20,418 patients receiving CT examination with non-ionic iodinated contrast agent at X-ray Department in Gansu Provincial Hospital from July 2013 to September 2016 were retrospectively analyzed.Results For observation objects in this group,11,679 were male and 8,739 female,aging from 3 to 93 and the average age was (52.1 ± 13.2) years.Various adverse reactions occurrence rate of non-ionic iodinated contrast agent was 0.4％ and adverse reactions occurrence rate of secondary hypertonic contrast and isotonic contrast agent was 0.47％ and 0.27％,respectively.Among the 81 adverse reactions,91.3％ were acute,among which 88.9％ occurred within 15 min after injection.8.7％ were delayed,97.6％ mild and moderate,and 2.4％ severe.Secondary hypertonic contrast and isotonic contrast agent occupied 74.0％ and 26.0％,respectively for the cause of adverse reactions.Delayed adverse reactions were mainly caused by isotonic contrast agent,representing as mild and moderate.Representation frequency of adverse reactions symptoms in turn was skin,digestive tract,central nervous system,respiratory system and circulatory system.Conclusion Adverse reactions caused by iodinated contrast agent were mainly acute and mild and moderate.The patients or their family members shall be fully notified before examinations.Severe adverse reactions caused by iodinated contrast agent developed very quickly and multi-systems would be damaged.Efficient on-site treatment is very important.Delayed reactions caused by isotonic contrast agent shall be paid more attention.
