Evaluating Prognosis of Multiple Myeloma by Different Infiltrative Patterns on Whole-body MRI
10.3969/j.issn.1005-5185.2017.11.014
- VernacularTitle:全身磁共振成像多发性骨髓瘤浸润类型评估预后的价值
- Author:
Min ZONG
1
;
Lidi WAN
;
Chang GAO
;
Yuefen ZOU
;
Yang FENG
;
Dehang WANG
Author Information
1. 南京医科大学第一附属医院放射科 江苏南京210029
- Keywords:
Multiple myeloma;
Magnetic resonance imaging;
Pathology,surgical;
Prognosis
- From:
Chinese Journal of Medical Imaging
2017;25(11):853-857
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the prognostic value of whole-body magnetic resonance imaging (WB-MRI) for patients with multiple myeloma (MM).Materials and Methods Sixty-two newly diagnosed patients with MM confirmed by pathology during January 2010 and December 2016 were enrolled in this study.The patients were divided into five groups according to the infiltrative patterns on MRI:normal pattern,micro-nodular pattern,macronodular pattern,mixed pattern and diffuse pattern,and their overall survival were compared.Results Of all the patients,micro-nodular infiltrative pattern was found in 20 patients,macro-nodular pattern in 13 patients,mixed pattern in 7 patients and diffuse pattern in 17 patients,while 5 patients were normal.During the follow-up for a median of 39 months (ranged 30.9-47.1 months),overall survival with the mixed MM infiltrative pattern (median 17 months,95％ CI 12.6-21.3 months) was statistically shorter than those with other patterns (median 43 months,95％ CI 33.7-52.3 months;P＜0.05).Additionally,the clinical DurieSalmon (DS) and International Staging System (ISS) were applied to evaluate the stage of MM patients.DS system showed that 6 patients were at stage I,another 6 patients were at stage Ⅱ and the other 50 patients were at stage Ⅲ.While based on ISS system,15 patients were found at stage Ⅰ,22 patients were at stage Ⅱ and the rest 25 patients were at stage Ⅲ.Meanwhile,the correlation between the WB-MRI infiltrative pattems and DS system as well as ISS system had no significant correlation (P＞0.05).Conclusion Different infiltrative patterns in WB-MRI can predict the prognosis in patients with MM at the time of diagnosis.
