CT spectral imaging assessment of synovial hemosiderin deposition in knee joint in patients with hemophilic arthropathy
10.13929/j.1003-3289.201801157
- VernacularTitle:CT能谱成像评估血友病性关节病患者膝关节滑膜含铁血黄素沉积
- Author:
Shufang WEI
1
;
Minghua SUN
;
Feifei GAO
;
Huina LIU
;
Pingchong LEI
;
Yinghui GE
Author Information
1. 郑州大学人民医院河南省人民医院放射科
- Keywords:
Hemophilia;
Hemosiderin;
Tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2018;34(6):924-928
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the value of CT spectral imaging in assessment of synovial hemosiderin deposition (SHD) in the knee joint in patients with hemophilic arthropathy (HA).Methods Twenty-five HA patients (40 assessable knees) underwent CT spectral imaging and MR scanning.According to the MRI international prophylaxis study group (IPSG) score of SHD,the knees were divided into mild group and severe group.CT value,iron (water) concentration (FeC),water (iron) concentration (WC),effective atomic number (Eff-Z) and average spectral curve slope (aSCS) of SHD area were measured and calculated,respectively.Meanwhile,the adjacent semi-membrane muscles in the same slice were taken as controls.The spectral parameters of CT were compared with One-Way ANOVA,and ROC curves were plotted to obtain the spectral parameters and the optical diagnostic threshold of SHD.Results CT value,FeC,and aSCS of SHD area were statistically significant among three groups (F=148.08,307.88,7.80,364.62 and 261.50,P＜0.01),and the differences of parameters between any two groups except WC were statistically significant (all P＜0.05).The area under ROC curve of SHD evaluated with aSCS was the largest,and the thresholds for the diagnosis of severe and mild SHD of aSCS was 1.84 and 0.42,respectively.Conclusion Multiple parameter analysis of CT spectral imaging is of great value for assessment of the severity of SHD in the knee joint in HA patients,therefore having important clinical significance.
