18F-FDG PET/CT in detection of recurrence and/or metastasis of differentiated thyroid carcinoma in patients with elevated serum thyroglobulin levels and negative 131I post-therapy whole body scan
10.13929/j.1003-3289.201711001
- VernacularTitle:18F-FDG PET/CT检测131I-治疗剂量全身显像阴性而甲状腺球蛋白阳性分化型甲状腺癌复发和转移
- Author:
Xu CHENG
1
;
Yongjun LI
;
Xindan XU
;
Zhaoqiang XU
;
Xiaojun YUAN
;
Lihua BAO
Author Information
1. 南京医科大学第一附属医院核医学科
- Keywords:
Positron-emission tomography;
Tomography,emission computed,single photon;
Fluorodeoxyglucose F18;
Thyroid neoplasms;
Thyroglobulin
- From:
Chinese Journal of Medical Imaging Technology
2018;34(6):855-859
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value and the impact on treatment decision of 18F-FDG PET/CT in differentiated thyroid carcinoma (DTC) patients with elevated serum thyroglobulin (Tg) levels and negative radioiodine 131I post-therapy whole body scan (131I-RxWBS).Methods Totally 72 patients with DTC who had elevated serum Tg levels and negative 131I-RxWBS were enrolled,and 18F-FDG PET/CT was performed.The imaging results of 18F-FDG PET/CT were compared with the clinical results of surgical pathology or 6 to 36 months follow up.The diagnostic efficacy of 18F-FDG PET/CT in detection of recurrence and/or metastasis of DTC with elevated Tg levels and negative 131I-RxWBS was evaluated.Results The accuracy,sensitivity,specificity,positive prediction value and negative prediction value of 18F-FDG PET/CT in diagnosis of DTC with elevated Tg levels and negative 131I-RxWBS was 83.33％ (60/72),89.47％ (34/38),76.47％ (26/34),80.95％ (34/42) and 86.67％ (26/30),respectively.18F-FDG PET/CT changed the treatment strategies of 35 patients (35/72,48.61 ％) among 72 patients,while recurrence or metastasis of DTC was not found during clinical follow-up in 23 of these 35 patients (23/35,65.71％) who underwent reoperation,but was detected in the other 12 patients (12/35,34.29％).Conclusion 18F-FDG PET/CT is a valuable method for detection of recurrence and/or metastasis of DTC with elevated Tg levels and negative 131I-RxWBS,also for guiding the follow-up treatment strategy.
