18F-FDG PET/CT imaging of subcortical structure in children with intractable epilepsy
10.13929/j.1003-3289.201710112
- VernacularTitle:儿童难治性癫痫18F-FDG PET/CT皮层下结构影像学分析
- Author:
Yan FAN
1
;
Zhenghao TONG
;
Jianhua ZHANG
;
Lijuan DI
;
Xuchu ZHANG
;
Zhanli FU
;
Yanfu WANG
;
Lixin CHEN
;
Rongfu WANG
Author Information
1. 北京大学第一医院核医学科
- Keywords:
Epilepsy;
Tomography,emission-computed;
Fluorodeoxyglucose F 18
- From:
Chinese Journal of Medical Imaging Technology
2018;34(5):656-659
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the metabolic changes of subcortical structures in children with intractable epilepsy using 18 F-FDG PET/CT,and to investigate the mechanism of subcortical structure involvement in epileptic seizures and its clinical significance.Methods Features of 18F-FDG PET/CT imaging in 611 intractable epilepsy children were analyzed.The metabolic changes of cortex and subcortical structures (basal ganglia,thalamus and cerebellum) were observed.The children were divided into three groups (young,middle and older groups) according to age,also mild group and severe group according to the number of involved lobar,respectively.The incidence of metabolic abnormalities in subcortical structures of different groups were analyzed.Results Among 611 children,unilateral cortical metabolic abnormality was found in 525,and bilateral cortical metabolic abnormalities were found in 86 children.The involvement of subcortical structures was detected in 190 children,including basal ganglia (n=64),thalamus (n=113) and cerebellum (n=105).The incidence of metabolic abnormality in subcortical structures under different age groups was not statistically different (all P＞ 0.05),while the incidence of metabolic abnormality in subcortical structures of severe group was significantly higher than that of mild group (all P＜0.001).Conclusion 18 F-FDG PET/CT might be able to detect the metabolic abnormalities of subcortical structures,therefore indicating the involvement of cerebral cortex.
