Efficacy of dynamic contrast-enhanced MRI in quantitative assessment of benign and malignant breast lesions
10.13929/j.1003-3289.201707125
- VernacularTitle:动态增强MRI定量评估乳腺良恶性病变的效能
- Author:
Conghui NAN
1
;
Wei ZHANG
;
Huiying WANG
;
Wei HUA
;
Baolin YUAN
Author Information
1. 中国医科大学附属盛京医院放射科
- Keywords:
Breast neoplasms;
Contrast media;
Magnetic resonance imaging;
Background parenchyma
- From:
Chinese Journal of Medical Imaging Technology
2018;34(4):558-562
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in evaluation of hemodynamic parameters of lesions and background parenchyma in benign and malignant breast lesions.Methods Breast DCE-MRI data were collected from 41 patients,including 21 benign lesions (benign group) and 24 malignant lesions (malignant group).Volume transfer constant (K),rate constant (Kep) and plasma fraction (Vp) of lesions and background parenchyma were measured,and the parameters of both groups were statistically analyzed.Taking pathological diagnosis as the gold standards,the efficacy of parameters in diagnosis of malignant breast lesions was evaluated.Results Ktrans and Kep of lesions and background parenchyma in the malignant group were higher than those in benign group (all P＜0.05).There was no significant difference between Vp of lesions and background parenchyma in both groups (both P＞0.05).In the diagnosis of malignant lesions,AUC of Ktrans of background parenchyma was the best,the sensitivity and specificity was 87.50％ and 76.19％,respectively.All parameters combined Logistic regression model had the highest AUC value (0.86,P＜0.001).Conclusion Among DCE-MRI related parameters,K of background parenchyma has the highest diagnostic value.Quantitative analysis of DCE-MRI data can help to identify benign and malignant breast lesions,and the hemodynamic characteristics of the background parenchyma are expected to be new methods for non-invasive diagnosis of breast lesions.
