Correlation between CT manifestations of intramural vascular abnormalities and pathological subtypes, ground glass types in ground-glass opacity lung adenocarcinoma
10.13929/j.1003-3289.201707059
- VernacularTitle:磨玻璃密度肺腺癌内血管异常CT表现与病理亚型及磨玻璃分型的相关性
- Author:
Liuqing KANG
1
;
Hailiang LI
;
Xiaoxian ZHANG
;
Yue WU
;
Xuejun CHEN
Author Information
1. 郑州大学附属肿瘤医院河南省肿瘤医院放射科
- Keywords:
Lung neoplasms;
Adenocarcinoma;
Pathology;
Tomography,X-ray computed
- From:
Chinese Journal of Medical Imaging Technology
2018;34(4):548-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between CT manifestations of intramural vascular abnormalities and pathological subtypes,ground glass types in ground-glass opacity (GGO) lung adenocarcinoma.Methods CT data of 50 patients (55 lesions) with GGO lung adenocarcinoma confirmed by operative pathology were analyzed.The vascular morphology was observed.Correlation between vascular abnormalities (vascular thickening and hyperplasia) and pathological subtypes,ground glass types in GGO lung adenocarcinoma were analyzed.Results Among 55 GGO lung adenocarcinoma lesions,5 were pre-invasive lesions,no vascular thickening was observed,whereas vascular increasing was noticed in 1 lesion.Among 16 minimally invasive adenocarcinomas (MIA),vascular thickening and vascular increasing were observed in 11 and 16 lesions,respectively.All 34 invasive adenocarcinomas (IAC) were found with vascular thickening and increasing.The overall difference of vascular thickening and vascular increasing among pre-invasive lesions,MIA and IAC was statistically significant (x2 =27.67,20.08,both P＜0.05).There was positive correlation between pathological subtypes and vascular thickening and vascular increasing (r=0.61,0.66,P＜0.01).Significant differences of vascular thickening were found between pre-invasive lesions and MIA (x2=9.19,P=0.01),pre-invasive lesions and IAC (x2 =29.87,P＜0.01),as well as MIA and IAC (x2 =12.63,P＜0.01).There were significant differences of vascular increasing between pre-invasive lesions and MIA,pre-invasive lesions and IAC (x2 =15.45,20.79,both P＜0.01).Of all 55 GGO lung adenocarcinoma lesions,25 were pGGO,17 with vascular thickening and 21 vascular increasing;30 were mGGO,28 with vascular thickening and 30 vascular increasing.There were significant differences of vascular thickening and increasing in pGGO and mGGO (x2=6.12,6.69,both P＜0.05).Conclusion Vascular abnormalities in GGO lung adenocarcinoma suggest increasing of invasion.Vascular thickening and increasing can occur independently.
