MR T2WI demonstration of sciatic nerve injury in rabbits
10.13929/j.1003-3289.201709157
- VernacularTitle:MR T2WI显示实验兔坐骨神经损伤
- Author:
Cancan CHEN
1
;
Di DAI
;
Xianhua WU
;
Xuejun ZHOU
;
Xiubin WANG
Author Information
1. 南通大学医学院研究生院
- Keywords:
Magnetic resonance imaging;
Sciatic nerve;
Peripheral nerve injury
- From:
Chinese Journal of Medical Imaging Technology
2018;34(3):321-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between MRI signal,pathological changes and neurological function after sciatic nerve injury in rabbits.Methods Twenty New Zealand white rabbits were randomly and evenly divided into 5 groups,and the right sciatic nerve crush models were established.T2 fat suppression fast recovery spin echo (T2 fs FRFSE) sequence scanning was performed 3 days,7 days,2 weeks,3 weeks and 4 weeks after injury,and TE was set as 30,60 and 90 ms,respectively.Signal intensity ratio (SIR) and relative signal intensity (△S) of proximal and distal part of injured nerve and control side nerve were measured.The relationship between SIR,△S,pathology and rabbit lower limb nerve function were analyzed.Results In the distal part of injured nerve,SIR and △S increased 3-7 days after injury,pathological results showed vacuolar degeneration,and basic toe function lost was found.SIR and △S reached the peak 2 weeks after injury,with most serious disintegration of myelin and toe function disable.SIR,△S and toe function disable gradually recovered,and the nerve regenerated at 3-4 weeks after injury.The injure display rate of T2 fs FRFSE images with TE=90 and 60 ms,SIR of both distal and proximal part of injured nerve were higher than those on images with TE=30 ms (all P＜0.05).Conclusion SIR and △S changes on T2 fs FRFSE imaging can be used to predict rabbit nerve injury.
