IVIM-DWI combined with MRS in differential diagnosis of osteoporotic fractures and metastatic vertebral compression fractures
10.13929/j.1003-3289.201706138
- VernacularTitle:IVIM-DWI联合MRS鉴别诊断骨质疏松与转移性椎体压缩性骨折
- Author:
Qiuju FAN
1
;
Hui TAN
;
Nan YU
;
Qi YANG
;
Shaoyu WANG
;
Taiping HE
;
Yong YU
;
Yu XUE
Author Information
1. 陕西中医药大学附属医院影像科
- Keywords:
Vertebra;
Osteoporosis;
Fractures;
Neoplasm metastasis;
Diffusion magnetic resonance imaging;
Magnetic resonance spectroscopy
- From:
Chinese Journal of Medical Imaging Technology
2018;34(2):297-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of intravoxel incoherent motion DWI (IVIM-DWI) combined with single-voxel MRS in distinguishing osteoporotic fractures from metastatic vertebral compression fractures.Methods Totally 70 patients with vertebral compression fractures,who underwent CT scanner were enrolled.The patients were divided into osteoporotic group or metastatic group based on pathological results or clinical follow-up.All patients underwent conventional sagittal T1W,T2W,STIR,IVIM-DWI and single-voxel MRS scanning.Relative peak areas of the signal of water at 4.7 ppm and lipid at 1.3 ppm were determined.IVIM-DWI parameters (diffusion coefficient [D],pseudo diffusion [D*],perfusion fraction [f]) and MRS parameters (lipid water ratio [LWR],fat fraction [FF]) were also recorded.The diagnostic performance of MRS,IVIM-DWI,as well as MRS combined with IVIM-DWI in distinguishing osteoporotic fractures from metastatic vertebral compression fractures were evaluated by using ROC curve,and the area under curve (AUC) was calculated.Results The f,D and FF in metastatic group were significantly lower than those in osteoporotic group,while D* in metastatic group was significantly higher than that in osteoporotic group (all P＜0.05).The sensitivity,specificity and accuracy in differentiating osteoporotic fractures from metastatic vertebral compression fractures was 87.50％ (28/32),57.89 (22/38) and 71.43％ (50/70) of MRS,78.13％ (25/32),89.47％ (34/38) and 84.28％ (59/70) of IVIM-DWI,90.63％ (29/32),97.37％ (37/38) and 94.29％ (66/70) of MRS combining with IVIM-DWI,respectively.AUC of MRS,IVIM-DWI,as well as MRS combined with IVIM-DWI was 0.73,0.88 and 0.94 (all P ＜0.05),respectively.Conclusion Combination of IVIM-DWI and MRS can improve the diagnostic efficiency of differentiating osteoporotic fractures from metastatic vertebral compression fractures.
