USPIO-enhanced MRI for lymph-node metastases from abdominal and pelvic malignancies: Meta-analysis
10.13929/j.1003-3289.201707072
- VernacularTitle:超微超顺磁性氧化铁增强MRI诊断腹盆部恶性肿瘤淋巴结转移:Meta分析
- Author:
Lulu XU
1
;
Jian SHU
;
Guoyun HE
;
Yan HU
;
Yu CAI
Author Information
1. 西南医科大学附属医院放射科
- Keywords:
Ultrasmall superparamagnetic iron oxide;
Magnetic resonance imaging;
Lymph nodes;
Meta-analysis
- From:
Chinese Journal of Medical Imaging Technology
2018;34(2):254-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate value of ultrasmall superparamagnetic iron oxide (USPIO)-enhanced MRI in diagnosis of lymph node metastasis from abdominal and pelvic malignancies with Meta-analysis.Methods A systematic search was conducted in PubMed,Embase,Cochrane Library,Wanfang,VIP and CNKI databases.The literature were screened according to inclusion and exclusion criteria,and four tabular data were extracted.With Meta Disc version 1.4 and STATA 11.0 software,statistical analysis was performed and heterogeneity of the included articles was tested.Based on the result of heterogeneity test,proper effect model was selected to calculate the pooled sensitivity and specificity.Summary receiver operating characteristics curve was obtained,and the area under curve (AUC) was calculated.Results Totally 20 English literature were enrolled,including 1 211 patients and 3 583 lymph nodes.The pooled sensitivity and specificity for USPIO-enhanced MRI in diagnosis of lymph node metastasis was 0.89 (95％CI [0.86,0.91]) and 0.96 (95 ％CI [0.95,0.96]),and AUC was 0.98,respectively.Regression analysis revealed that the heterogeneity may result from the location of tumors,and subgroup analysis showed that pooled sensitivity in diagnosis of lymph node metastasis in abdominal malignancies was good.Conclusion USPIO-enhanced MRI has good diagnostic efficacy in diagnosis of lymph node metastasis from abdominal and pelvic malignancies.
