CEUS in quantitative evaluation of vulnerable plaques in patients with large artery atherosclerosis stroke: Correlation with leukocytes
10.13929/j.1003-3289.201708002
- VernacularTitle:CEUS定量评估大动脉粥样硬化性脑卒中患者易损斑块及其与循环血白细胞的相关性
- Author:
Zhaojun LI
1
;
Yun BAI
;
Wanbin LI
;
Feng GAO
;
Yi KUANG
;
Lianfang DU
;
Xianghong LUO
Author Information
1. 上海交通大学附属第一人民医院超声科
- Keywords:
Ultrasonography;
Contrast media;
Plaque,atherosclerotic;
Carotid arteries
- From:
Chinese Journal of Medical Imaging Technology
2018;34(2):223-227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the correlation between CEUS quantitative parameters of carotid plaques and leukocytes in patients with acute ischemic stroke.Methods Sixty-two patients with large artery atherosclerosis stroke (LAAS group) confirmed by CT or MRI were enrolled,while 54 patients in the same period of hospitalization,age and gender-matched,no history of cardiovascular events with atherosclerosis were taken as control group.The correlation between CEUS quantitative parameters of carotid plaques and leukocytes in two groups were compared.Multiple linear regression model was built and the risk factors of CEUS quantitative parameters were analyzed.Results The total leukocytes count,neutrophils count and neutrophil/lymphocyte ratio in LAAS group were higher,while the lymphocytes count was lower than those in control group (all P＜0.05).CEUS parameters,including timeqntensity curve (TIC) peak (TIC-P),mean (TIC-M),fitting curve (FC) peak (FC-P),sharpness (FC-S) and area under the curve (FC-AUC) of carotid plaques were higher than those in control group (all P＜0.05),while neutrophils count and neutrophil/lymphocyte ratio were positively correlated with FC-AUC (r=0.298 and 0.739,respectively;all P＜0.05).Total leukocytes count was independent risk factor of TIC-P,and neutrophil/lymphocyte ratio was independent risk factor of FC-AUC (all P＜0.05).Conclusion CEUS quantitative parameters of carotid plaques related to leukocytes count.Increased leukocytes or neutrophil/ lymphocyte ratio might rise vulnerability of plaques.
