Quantitative evaluation of blood-brain barrier permeability in patients with ischemic white matter lesions with dynamic contrast-enhanced MRI
10.13929/j.1003-3289.201708166
- VernacularTitle:动态增强MRI定量评价缺血性脑白质病患者血脑屏障通透性
- Author:
Man LI
1
;
Yue LI
;
Shuai GAO
;
Mingxi LIU
;
Yang ZHOU
;
Long ZUO
;
Wenli HU
;
Tao JIANG
Author Information
1. 首都医科大学附属北京朝阳医院放射科
- Keywords:
Brain ischemia;
White matter;
Blood-brain barrier;
Permeability;
Magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2018;34(2):181-184
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of blood-brain barrier (BBB) permeability and the correlation with cognitive function in patients with ischemic white matter disease with dynamic contrast-enhanced MRI (DCE-MRI).Methods Totally 71 subjects underwent routine MRI,DCE-MRI,mini-mental state examination (MMSE) and Fazekas scoring,and then were divided into patient group and control group according to the Fazekas scores.The leakage rate (K),area under the leakage curve (AUC) and fractional blood plasma volume (Vp) in cerebral white matter hyperintensities area and normal appearing white matter area were measured and compared between the two groups.The correlation between these parameters and MMSE scores were analyzed.Results K and AUC value of white matter hyperintensities area and normal appearing white matter area in patient group were significantly higher than those in control group (all P＜0.001).Vp value of normal appearing white matter area in patient group was lower than that in control group (P=0.015).K and AUC value of white matter hyperintensities area in patient group had significant negative correlation with MMSE scores (r=-0.440,--0.540,both P＜0.001).Conclusion BBB permeability increased in cerebral white matter hyperintensities and normal appearing white matter area in patients with ischemic white matter lesions,which correlated with cognitive function.
