Assessment of left ventricular function in HeFH patients with myocardial layer-specific analysis based on two-dimensional echocardiography
10.13929/j.1003-3289.201708152
- VernacularTitle:基于二维超声心动图心肌分层应变技术评估HeFH患者左心室功能
- Author:
Lin LIU
1
;
Rongjuan LI
;
Zhaoting LENG
;
Yijia LI
;
Yueli WANG
;
Ya YANG
;
Lihong PU
;
Guowen LIU
Author Information
1. 首都医科大学附属北京安贞医院超声心动图室
- Keywords:
Heterozygote;
Genetics;
Hypercholesterolemia;
Strain;
Echocardiography
- From:
Chinese Journal of Medical Imaging Technology
2018;34(1):47-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of layer-specific strain in assessment of left ventricular function in patients with heterozygous familial hypercholesterolemia (HeFH) with normal left ventricular ejection fraction (LVEF).Methods Thirty-four patients with diagnosed HeFH and underwent transthoracic echocardiography were included as HeFH group,while 29 healthy volunteers were taken as control group.EchoPAC software was used to obtain endocardial longitudinal strain (LSendo),myocardial longitudinal strain (LSmyo) and epicardial longitudinal strain (LSepi) of the epicardial,and then statistical analysis was performed.Results LSendo and LSmyo in HeFH group were significantly lower than those in control group (P＜0.001).LSendo and LSmyo were negatively correlated with total cholesterol and low density lipoprotein cholesterol (all P＜0.05).Conclusion Layer-specific strain of left ventricular is of great value in assessing early myocardial damage in patients with HeFH.
