The correlation between carotid plaque stability and the serum level of Hs-CRP, MMP-9 and TIMP-1
10.3760/cma.j.issn.1008-1372.2018.10.017
- VernacularTitle:颈动脉斑块稳定性与血清hs-CRP、MMP-9、TIMP-1表达水平的相关性研究
- Author:
Shangwei DING
1
;
Yuhuan XIE
;
Runxiong LI
;
Genpei LUO
;
Qiaoqiong CHEN
;
Yue PENG
;
Huanru GUO
Author Information
1. 南方医科大学附属东莞人民医院超声科
- Keywords:
Carotid artery diseases/ME;
Atherosclerosis/ME;
C-reactive protein/ME;
Matrix metalloproteinase 9/ME;
Tissue inhibitor of metalloproteinase-1/ME
- From:
Journal of Chinese Physician
2018;20(10):1506-1509
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study on the relationship between the serum level of highsensitivity c-reaction protein (hs-CR),matrix metalloproteinase 9 (MMT-9),tissue inhibitor of metalloproteinase 1 (TIMP-1) and carotid plaque stability in elderly people.Methods According to the carotid ultrasonography examination,120 old people were divided into vulnerable plaque group (group A,n =45),stable plaque group (group B,n =41) and no plaque group (group C,n =34),and serum levels of hs-CRP,MMP-9,TIMP-1 in each group were also detected.Results The serum levels of hs-CRP and MMP-9 of unstable plaque group and stable plaque group were higher than those of non-plaque group (P ＜ 0.05).hsCRP and MMP-9 were positively correlated with carotid plaque unstability,while TIMP-1 was negatively correlated with carotid plaque unstability,hs-CRP,MMP-9 and TIMP-1 were independent risk factors for carotid plaque stability.Conclusions Serum levels of hs-CRP,MMP-9 and TIMP-1 are closely related to the stability of carotid plaque.Elevated levels of hs-CRP and MMP-9 increase the risk of carotid plaque,and elevated levels of TIMP-1 decrease the risk of carotid plaque.
