Difference of the clinical characteristics and outcome between interstitial lung disease with dermatomyositis and idiopathic pneumonia fibrosis
10.3760/cma.j.issn.1008-1372.2018.10.015
- VernacularTitle:皮肌炎相关间质性肺病与特发性肺纤维化临床特征与预后的差异
- Author:
Dingyun FENG
1
;
Xiaoling ZOU
;
Hailing YANG
;
Heliang LI
;
Yuqi ZHOU
;
Tiantuo ZHANG
Author Information
1. 中山大学附属第三医院呼吸内科
- Keywords:
Dermatomyositis/CO;
Lung diseases,interstitial/ET/DI;
Pulmonary fibrosis/DI;
Diagnosis,differential
- From:
Journal of Chinese Physician
2018;20(10):1498-1501
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical features and prognosis between dermatomyositis-associated interstitial lung disease (DM-ILD) and idiopathic pulmonary fibrosis (IPF).Methods Patients with interstitial lung disease with dermatomyositis (DM-ILD) or idiopathic pneumonia fibrosis (IPF) from January 2003 to March 2014 in the third affiliated hospital of Sun Yat-sen University were included.Results Among the 64 patients enrolled,44 were DM-ILD and 20 were IPF.IPF was more common in the elderly (P =0.000),men (P =0.004) and smokers (P =0.000),and its high-resolution computed tomography (CT) mostly showed grid shadow (P=0.014) and honeycomb shadow (P=0.000).DM-ILD usually had cough symptoms (P =0.025).High-resolution CT showed patchy (P =0.048) and banded (P =0.000).Glucocorticoid (P =0.000) and immunosuppressive agents (P =0.000) were commonly used in the treatment of DM-ILD.However,there was no significant difference in 90d mortality between the two groups (P ＞ 0.05).Conclusions IPF is more common in the elderly,men and smokers,and its high-resolution CT mostly shows grid shadow and honeycomb shadow,distribution is diffuse.DM-ILD often has cough symptoms,and its high resolution CT is mostly plaques and streaky shadows.Glucocorticoids and immunesuppressants are commonly used in DM-ILD,but there is no significant difference in 90-day mortality between them.
