Association between matrix metalloproteinase-9 gene polymorphism and delayed cerebral edema in patients with hypertensive intracerebral hemorrhage
10.3760/cma.j.issn.1008-1372.2018.09.021
- VernacularTitle:基质金属蛋白酶-9基因多态性与高血压脑出血患者迟发性脑水肿的相关性研究
- Author:
Yuan SHI
1
;
Yingying LIU
;
Wenying QU
;
Hui HUI
Author Information
1. 716000,延安大学附属医院神经内科
- Keywords:
Matrix metalloproteinase 9/GE;
Polymorphism,genetic;
Intracranial hemorrhage,hypertensive/CO;
Brain edema/CO
- From:
Journal of Chinese Physician
2018;20(9):1359-1362,1366
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between matrix metalloproteinase-9 (MMP-9) gene polymorphism and delayed cerebral edema in patients with hypertensive intracerebral hemorrhage (HICH).Methods 137 HICH patients were recruited to participate in the study.According to whether combined with delayed cerebral edema,they were divided into the case group (42 cases) and the control group (95 cases).Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-FLP) for MMP-9 gene-1562C/T polymorphism.Clinical data was collected for statistical analysis.Results There was significant difference in age,diabetes,persistent fever,baseline hematoma volume and National Institute of Health Stroke Scale (NIHSS) between the case group and the control group (all P ＜ 0.05).Meanwhile,serum MMP-9 level of the case group was significantly higher than that of the control group [(176.7 ± 50.3) mg/L vs (145.8 ± 41.3) mg/L,P =0.000].There were significant difference in serum MMP-9 level between genotype CC and genotype (CT + TT) [(147.3 ± 45.0) mg/L vs (189.2 ± 59.4)mg/L,P =0.000].Compared with the control group,the distribution frequencies of allele T in the case group was significantly increased (P =0.019).Multivariatc Logistic regression analysis showed that Allele T was a risk factor of delayed cerebral edema for HICH patients (OR =2.612,95％ CI:1.187-6.670,P =0.005).Conclusions For spontaneous HICH patients,MMP-9 gene-1562C/T polymorphism may closely related to delayed cerebral edema.
