Clinical analysis of 51 children with seizure secondary to tuberous sclerosis

VernacularTitle:儿童结节性硬化症合并癫痫51例临床分析
Author: Juan YANG ¹ ; Xiaolu DENG ; Chen CHEN ; Lifen YANG ; Pan PENG ; Xiaole WANG
Author Information

1. 中南大学湘雅医院儿科
Keywords: Tuberous sclerosis/CO; Epilepsy/CO; Child
From: Journal of Chinese Physician 2018;20(9):1284-1287
CountryChina
Language:Chinese
Abstract: Objective To analyze the clinical characteristics and treatment of children with tuberous sclerosis (TSC) complicated with epilepsy,so as to improve the level of diagnosis and treatment and improve the prognosis of children with TSC.Methods The clinical data of TSC children complicated with epilepsy diagnosed and followed up in Xiangya Hospital of Central South University were collected and analyzed retrospectively.Results Of the 51 children,49 (96.1％) had their first visit because of epileptic seizures.Their electroencephalogram (EEG) showed epileptiform discharges during the epileptic period.The therapeutic effect of vigabatrin on TSC patients with spastic seizures was significantly different from that of antiepileptic drugs alone or in combination.Conclusions Epileptic seizure is the most common reason for first visit and seizure control will affect the prognosis of children to a large extent.Vigabatrin had remarkable effect on TSC patients with spasm seizure,and rapamycin has broad prospects in the treatment of children with TSC.