Effect of Yupingfeng granule on Th17/Treg balance in children with milk protein allergy
10.3760/cma.j.issn.1008-1372.2018.08.014
- VernacularTitle:玉屏风颗粒对牛奶蛋白过敏患儿Th17/Treg平衡的影响
- Author:
Yuanyuan ZHANG
1
;
Jianping TANG
;
Yongqi LUO
;
Zhu WEI
Author Information
1. 湖南省儿童医院皮肤科
- Keywords:
Milk proteins/AE;
Milk hypersensitivity/DT;
YUPINGFENG POWDERS/TU;
Th17 cells/IM;
T-lymphocytes,regulatory/IM;
Child
- From:
Journal of Chinese Physician
2018;20(8):1171-1175
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe Thl7 cells,Treg cells and their related factors in peripheral blood of children with milk protein allergy and explore the influence of Yupingfeng granule on Th17 / Treg imbalance and its clinical effect.Methods 40 children with milk protein allergy were divided into two groups randomly:the conventional treatment group (n =20),Yupingfeng granule group (n =20).The conventional treatment group received conventional treatment for 2 months.On the basis of routine treatment,Yupingfeng granule group was additionally treated with Yuping feng granule.The serum Th17,Treg cell counts,interleukin (IL)-17 and transforming growth factor-β1 (TGF-β1) levels were detected,and the eczema area and severity index (EASI) score of rash in children was recorded.Results The levels of Th17 cells and IL-17 in allergy children were obviously increased compared with those of the normal children,while the Treg cells,and the TGF-β1 level were lower than those of the normal children (P ＜ 0.05).After treatment,the Thl7 cells,the IL-17 levels and ESAI scores of the conventional treatment group and the Yupingfeng granule group were lowered,while the Treg cells and the TGF-β1 levels were increased (P ＜ 0.05).Compared with the conventional treatment group,these indexes increased and decreased more significantly in the Yupingfeng granule group (P ＜ 0.05).Conclusions Milk allergy children have obvious imbalance of Thl7/Treg;the Yupingfeng granule can adjust this imbalance and alleviate the allergic symptoms of milk protein.
