The role of ABCC2 gene in drug-resistant epilepsy
10.3760/cma.j.issn.1008-1372.2018.06.009
- VernacularTitle:ABCC2基因多态性与耐药性癫痫的相关性分析
- Author:
Yanli YANG
1
;
Xi HU
;
Dong SHU
;
Qiuxiang LUO
;
Furong ZHENG
;
Zongqian WU
;
Dongqiong XIE
Author Information
1. 四川省科学城医院神经内科
- Keywords:
Multidrug resistance-associated proteins/GE;
Polymorphism,single nucleotide;
Epilepsy
- From:
Journal of Chinese Physician
2018;20(6):836-838,843
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of the ATP binding box C subfamily 2 transporter protein (ABCC2) gene in drug-resistant epilepsy.Methods From February 2014 to February 2018,204 epileptic patients were treated in our hospital,including 41 cases of drug resistance epilepsy (drug resistance group),163 cases of non drug resistant epilepsy (sensitive group).The rs717620 polymorphism of ABCC2 gene and the level of P-glycoprotein (P-gp) in cerebrospinal fluid and serum were detected in two groups.Results The proportion of genotype TT and gene frequency T in the drug resistant group were 24.39％ and 41.46％,respectively,which were significantly higher than those in the sensitive group (P ＜ 0.05).The concentration of P-gp in cerebrospinal fluid of drug resistant group was (21.03 ± 4.21) ng/ml,which was significantly higher than that of the sensitive group (P ＜ 0.05).There was no significant difference in serum P-gp concentration between the drug resistant group and the sensitive group (P ＞ 0.05);The concentration of P-gp in cerebrospinal fluid of patients with genotype TT in drug resistance group was (24.03 ± 3.57) ng/ml,which was significantly higher than that of type CC and CT (P ＜ 0.05).There was no significant difference in the concentration of P-gp in the patients with different genotypes in the drug resistant group (P ＞ 0.05).Conclusions The rs717620 polymorphism of ABCC2 gene may be associated with drug-resistant epilepsy,and may be related to P-gp level in the cerebrospinal fluid.
