Clinical significance of monitoring the serum levels of Tg and TgAb in the 131I ablation therapy for patients with differentiated thyroid cancer
10.3760/cma.j.issn.1008-1372.2018.05.013
- VernacularTitle:监测血清Tg和TgAb水平在分化型甲状腺癌患者131I“清甲”治疗中的临床意义
- Author:
Xiaojie LIU
1
;
Zhigang ZHANG
;
Shuxing GAO
Author Information
1. 314000,浙江省嘉兴市第一医院核医学科
- Keywords:
Thyroid neoplasms/TH/BL;
Iodine isotopes/TU;
Thyroglobulin/BL;
Autoantibodies/BL
- From:
Journal of Chinese Physician
2018;20(5):689-692
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of monitoring the serum levels of Thyroglobulin (Tg) and Thyroglobulin Autoantibody (TgAb) in the 131I ablation therapy for patients with differentiated thyroidcarcinoma (DTC).Methods 102 patients with DTC treated by 131I ablation therapy in our hospital from May 2014 to July 2016 were selected.The serum levels of Tg and TgAb were detected by radioimmunoassay before 131I ablation therapy,6 months after I 13 1I ablation therapy and 12 months after 131I ablation therapy.The body imaging were performed at seventh days after 1311 ablation therapy.Results The serum levels of Tg and TgAb at 6 months and 12 months after surgery were significantly lower than those before operation,and the difference were statistically significant (t =9.260,17.507,2.534,4.797,P ＜ 0.05).The serum levels of Tg and TgAb in metastasis group were higher than that in non-metastasis group (t =10.257,7.353,P ＜0.05).The serum levels of Tg and TgAb in the effective group were lower than those in the ineffective group,and the difference were statistically significant (t =7.325,4.978,P ＜ 0.05).The positive rate of Tg combined with TgAb was similar with 131I-WBS screening methods and the difference was not statistically significant (P ＞ 0.05).The positive rate of Tg screening method and the positive rate of TgAb were higher than that of 131I-WBS screening method,but the difference was not statistically significant (P ＞ 0.05).Conclusions The level of serum Tg and TgAb is an important reference index for the efficacy,metastasis and recurrence of DTC after operation,and Tg combined with TgAb has a higher accuracy in the screening prognosis of DTC after operation.
